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Inhibition of nucleolar transcription as a trigger for neuronal apoptosis
In postmitotic neurons, the mechanisms of the apoptotic checkpoint that is activated by DNA damage remain unclear. Here we show that in cultured cortical neurons, the DNA damaging agent camptothecin (CPT) reduced transcription of rRNA and disrupted nucleolar staining for B23/nucleophosmin suggesting...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2909334/ https://ncbi.nlm.nih.gov/pubmed/18315559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2008.05316.x |
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