Inhibition of nucleolar transcription as a trigger for neuronal apoptosis

In postmitotic neurons, the mechanisms of the apoptotic checkpoint that is activated by DNA damage remain unclear. Here we show that in cultured cortical neurons, the DNA damaging agent camptothecin (CPT) reduced transcription of rRNA and disrupted nucleolar staining for B23/nucleophosmin suggesting...

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Bibliographic Details
Main Authors:	Kalita, Katarzyna, Makonchuk, Denys, Gomes, Cynthia, Zheng, Jing-Juan, Hetman, Michal
Format:	Artigo
Language:	Inglês
Published:	2008
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2909334/ https://ncbi.nlm.nih.gov/pubmed/18315559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2008.05316.x
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Inhibition of nucleolar transcription as a trigger for neuronal apoptosis

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