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Epigenetic Silencing of Nucleolar rRNA Genes in Alzheimer's Disease
BACKGROUND: Ribosomal deficits are documented in mild cognitive impairment (MCI), which often represents an early stage Alzheimer's disease (AD), as well as in advanced AD. The nucleolar rRNA genes (rDNA), transcription of which is critical for ribosomal biogenesis, are regulated by epigenetic...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3142181/ https://ncbi.nlm.nih.gov/pubmed/21799908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022585 |
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