Targeted editing of the PSIP1 gene encoding LEDGF/p75 protects cells against HIV infection

To fulfill a productive infection cycle the human immunodeficiency virus (HIV) relies on host-cell factors. Interference with these co-factors holds great promise in protecting cells against HIV infection. LEDGF/p75, encoded by the PSIP1 gene, is used by the integrase (IN) protein in the pre-integra...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Lampi, Yulia, Van Looveren, Dominique, Vranckx, Lenard S., Thiry, Irina, Bornschein, Simon, Debyser, Zeger, Gijsbers, Rik
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6382798/
https://ncbi.nlm.nih.gov/pubmed/30787394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-38718-0
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