Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P(2)/PI(3,4)P(2)

Phosphatidylinositol phosphates (PIPs) and cholesterol are known to regulate the function of late endosomes and lysosomes (LELs), and ORP1L specifically localizes to LELs. Here, we show in vitro that ORP1 is a PI(4,5)P(2)- or PI(3,4)P(2)-dependent cholesterol transporter, but cannot transport any PI...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Dong, Jiangqing, Du, Ximing, Wang, Huan, Wang, Jue, Lu, Chang, Chen, Xiang, Zhu, Zhiwen, Luo, Zhipu, Yu, Li, Brown, Andrew J., Yang, Hongyuan, Wu, Jia-Wei
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6381110/
https://ncbi.nlm.nih.gov/pubmed/30783101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08791-0
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