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Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P(2)/PI(3,4)P(2)
Phosphatidylinositol phosphates (PIPs) and cholesterol are known to regulate the function of late endosomes and lysosomes (LELs), and ORP1L specifically localizes to LELs. Here, we show in vitro that ORP1 is a PI(4,5)P(2)- or PI(3,4)P(2)-dependent cholesterol transporter, but cannot transport any PI...
Uloženo v:
| Vydáno v: | Nat Commun |
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| Hlavní autoři: | , , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6381110/ https://ncbi.nlm.nih.gov/pubmed/30783101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08791-0 |
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