Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P(2)/PI(3,4)P(2)

Phosphatidylinositol phosphates (PIPs) and cholesterol are known to regulate the function of late endosomes and lysosomes (LELs), and ORP1L specifically localizes to LELs. Here, we show in vitro that ORP1 is a PI(4,5)P(2)- or PI(3,4)P(2)-dependent cholesterol transporter, but cannot transport any PI...

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Publicado en:Nat Commun
Autores principales: Dong, Jiangqing, Du, Ximing, Wang, Huan, Wang, Jue, Lu, Chang, Chen, Xiang, Zhu, Zhiwen, Luo, Zhipu, Yu, Li, Brown, Andrew J., Yang, Hongyuan, Wu, Jia-Wei
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6381110/
https://ncbi.nlm.nih.gov/pubmed/30783101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08791-0
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