PI(4,5)P(2) controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER–PM contact sites

Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) is a critically important regulatory lipid of the plasma membrane (PM); however, little is known about how cells regulate PM PI(4,5)P(2) levels. Here, we show that the phosphatidylinositol 4-phosphate (PI4P)/phosphatidylserine (PS) transfer activit...

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Vydáno v:J Cell Biol
Hlavní autoři: Sohn, Mira, Korzeniowski, Marek, Zewe, James P., Wills, Rachel C., Hammond, Gerald R.V., Humpolickova, Jana, Vrzal, Lukas, Chalupska, Dominika, Veverka, Vaclav, Fairn, Gregory D., Boura, Evzen, Balla, Tamas
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2018
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940310/
https://ncbi.nlm.nih.gov/pubmed/29472386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201710095
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