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ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P(2)) and regulate its level at the plasma membrane

ORP5 and ORP8, members of the oxysterol-binding protein (OSBP)-related proteins (ORP) family, are endoplasmic reticulum membrane proteins implicated in lipid trafficking. ORP5 and ORP8 are reported to localize to endoplasmic reticulum–plasma membrane junctions via binding to phosphatidylinositol-4-p...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ghai, Rajesh, Du, Ximing, Wang, Huan, Dong, Jiangqing, Ferguson, Charles, Brown, Andrew J., Parton, Robert G., Wu, Jia-Wei, Yang, Hongyuan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5624964/
https://ncbi.nlm.nih.gov/pubmed/28970484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00861-5
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