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ORP2 couples LDL‐cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P(2) exchange

Low‐density lipoprotein (LDL)‐cholesterol delivery from late endosomes to the plasma membrane regulates focal adhesion dynamics and cell migration, but the mechanisms controlling it are poorly characterized. Here, we employed auxin‐inducible rapid degradation of oxysterol‐binding protein‐related pro...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Takahashi, Kohta, Kanerva, Kristiina, Vanharanta, Lauri, Almeida‐Souza, Leonardo, Lietha, Daniel, Olkkonen, Vesa M, Ikonen, Elina
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8281050/
https://ncbi.nlm.nih.gov/pubmed/34124795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020106871
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