PI(4,5)P(2) regulates plasma cholesterol through LDL receptor lysosomal degradation

OBJECTIVE: Transmembrane protein 55B (TMEM55B) is a phosphatidylinositol-(4,5)-bisphosphate (PI(4,5)P(2)) phosphatase that regulates cellular cholesterol, modulates LDL receptor (LDLR) decay and lysosome function. We tested the effects of Tmem55b knockdown on plasma lipids in mice, and assessed the...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Qin, Yuanyuan, Ting, Flora, Kim, Mee J, Strelnikov, Jacob, Harmon, Joseph, Gao, Feng, Dose, Andrea, Teng, Ba-Bie, Alipour, M. Amir, Yao, Zemin, Crooke, Rosanne, Krauss, Ronald M., Medina, Marisa W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7197750/
https://ncbi.nlm.nih.gov/pubmed/32188273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.314033
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