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Prediction of LDL cholesterol response to statin using transcriptomic and genetic variation

BACKGROUND: Statins are widely prescribed for lowering LDL-cholesterol (LDLC) levels and risk of cardiovascular disease. There is, however, substantial inter-individual variation in the magnitude of statin-induced LDLC reduction. To date, analysis of individual DNA sequence variants has explained on...

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Hlavní autoři: Kim, Kyungpil, Bolotin, Eugene, Theusch, Elizabeth, Huang, Haiyan, Medina, Marisa W, Krauss, Ronald M
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180544/
https://ncbi.nlm.nih.gov/pubmed/25316374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0460-9
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