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Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine
Animal cells acquire cholesterol from receptor-mediated uptake of low-density lipoprotein (LDL), which releases cholesterol in lysosomes. The cholesterol moves to the endoplasmic reticulum (ER), where it inhibits production of LDL receptors, completing a feedback loop. Here we performed a CRISPR-Cas...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7414171/ https://ncbi.nlm.nih.gov/pubmed/32690708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2010682117 |
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