3.3 Å structure of Niemann–Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport

Niemann–Pick C1 (NPC1) and NPC2 proteins are indispensable for the export of LDL-derived cholesterol from late endosomes. Mutations in these proteins result in Niemann–Pick type C disease, a lysosomal storage disease. Despite recent reports of the NPC1 structure depicting its overall architecture, t...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Li, Xiaochun, Lu, Feiran, Trinh, Michael N., Schmiege, Philip, Seemann, Joachim, Wang, Jiawei, Blobel, Günter
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576846/
https://ncbi.nlm.nih.gov/pubmed/28784760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711716114
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