Niemann-Pick C1 protein: Obligatory roles for N-terminal domains and lysosomal targeting in cholesterol mobilization

Niemann-Pick type C (NPC) disease is an inherited lipid storage disorder that affects the viscera and central nervous system. A characteristic feature of NPC cells is the lysosomal accumulation of low density lipoprotein-derived cholesterol. To elucidate important structural features of the recently...

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發表在:	Proc Natl Acad Sci U S A
Principais autores:	Watari, Hidemichi, Blanchette-Mackie, E. Joan, Dwyer, Nancy K., Glick, Jane M., Patel, Shutish, Neufeld, Edward B., Brady, Roscoe O., Pentchev, Peter G., Strauss, Jerome F.
格式:	Artigo
語言:	Inglês
出版:	National Academy of Sciences 1999
主題:	Biological Sciences
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15306/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9927649/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.3.805
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