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Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies

Cooption of the host vasculature is a strategy that some cancers use to sustain tumor progression without—or before—angiogenesis or in response to antiangiogenic therapy. Facilitated by certain growth factors, cooption can mediate tumor infiltration and confer resistance to antiangiogenic drugs. Unf...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Voutouri, Chrysovalantis, Kirkpatrick, Nathaniel D., Chung, Euiheon, Mpekris, Fotios, Baish, James W., Munn, Lance L., Fukumura, Dai, Stylianopoulos, Triantafyllos, Jain, Rakesh K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6377457/
https://ncbi.nlm.nih.gov/pubmed/30700544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818322116
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