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Combining microenvironment normalization strategies to improve cancer immunotherapy

Advances in immunotherapy have revolutionized the treatment of multiple cancers. Unfortunately, tumors usually have impaired blood perfusion, which limits the delivery of therapeutics and cytotoxic immune cells to tumors and also results in hypoxia—a hallmark of the abnormal tumor microenvironment (...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Mpekris, Fotios, Voutouri, Chrysovalantis, Baish, James W., Duda, Dan G., Munn, Lance L., Stylianopoulos, Triantafyllos, Jain, Rakesh K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035612/
https://ncbi.nlm.nih.gov/pubmed/32015113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1919764117
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