Opposing Roles of apolipoprotein E in aging and neurodegeneration

Apolipoprotein E (APOE) effects on brain function remain controversial. Removal of APOE not only impairs cognitive functions but also reduces neuritic amyloid plaques in mouse models of Alzheimer’s disease (AD). Can APOE simultaneously protect and impair neural circuits? Here, we dissociated the rol...

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Detalhes bibliográficos
Publicado no:Life Sci Alliance
Main Authors: Hudry, Eloise, Klickstein, Jacob, Cannavo, Claudia, Jackson, Rosemary, Muzikansky, Alona, Gandhi, Sheetal, Urick, David, Sargent, Taylie, Wrobleski, Lauren, Roe, Allyson D, Hou, Steven S, Kuchibhotla, Kishore V, Betensky, Rebecca A, Spires-Jones, Tara, Hyman, Bradley T
Formato: Artigo
Idioma:Inglês
Publicado em: Life Science Alliance LLC 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6374993/
https://ncbi.nlm.nih.gov/pubmed/30760557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900325
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