Opposing Roles of apolipoprotein E in aging and neurodegeneration

Apolipoprotein E (APOE) effects on brain function remain controversial. Removal of APOE not only impairs cognitive functions but also reduces neuritic amyloid plaques in mouse models of Alzheimer’s disease (AD). Can APOE simultaneously protect and impair neural circuits? Here, we dissociated the rol...

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Publicado en:Life Sci Alliance
Autores principales: Hudry, Eloise, Klickstein, Jacob, Cannavo, Claudia, Jackson, Rosemary, Muzikansky, Alona, Gandhi, Sheetal, Urick, David, Sargent, Taylie, Wrobleski, Lauren, Roe, Allyson D, Hou, Steven S, Kuchibhotla, Kishore V, Betensky, Rebecca A, Spires-Jones, Tara, Hyman, Bradley T
Formato: Artigo
Lenguaje:Inglês
Publicado: Life Science Alliance LLC 2019
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6374993/
https://ncbi.nlm.nih.gov/pubmed/30760557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900325
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