Isoform- and cell type-specific structure of apolipoprotein E lipoparticles as revealed by a novel Forster resonance energy transfer assay

Apolipoprotein E (apoE) has an important role in the pathogenesis of Alzheimer's disease with its three isoforms having distinct effects on disease risk. Here, we assessed the conformational differences between those isoforms using a novel flow cytometry-Forster resonance energy transfer (FRET)...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Kara, Eleanna, Marks, Jordan D., Fan, Zhanyun, Klickstein, Jacob A., Roe, Allyson D., Krogh, Kelly A., Wegmann, Susanne, Maesako, Masato, Luo, Christina C., Mylvaganam, Ravi, Berezovska, Oksana, Hudry, Eloise, Hyman, Bradley T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5592654/
https://ncbi.nlm.nih.gov/pubmed/28684412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.784264
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