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Demethylation and epigenetic modification with 5-azacytidine reduces IDH1 mutant glioma growth in combination with temozolomide
BACKGROUND: Isocitrate deyhydrogenase (IDH) mutant glioma comprises the majority of grades II–III gliomas and nearly all secondary glioblastomas. These progressive gliomas arise from mutations in IDH1 or IDH2 that pathologically produce D-2-hydroxyglutarate (2HG), which interferes with cell reaction...
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| Publicado no: | Neuro Oncol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6374765/ https://ncbi.nlm.nih.gov/pubmed/30184215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy146 |
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