Nalaganje...
OPTIMIZATION OF DEMETHYLATING THERAPY FOR IDH1 MUTANT GLIOMAS
BACKGROUND: Mutations in Isocitrate Dehydrogenase 1 (IDH1) are found in the majority of grade II and III gliomas and the subsequent progressive GBMs. The mutant IDH1 enzyme produces 2-hydroxyglutarate (2-HG), an “oncometabolite” that inhibits α-ketogluterate dependent histone and DNA demethylases re...
Shranjeno v:
| Main Authors: | , |
|---|---|
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2014
|
| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4144578/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou208.32 |
| Oznake: |
Označite
Brez oznak, prvi označite!
|