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Altered cancer cell metabolism in gliomas with mutant IDH1 or IDH2
PURPOSE OF REVIEW: IDH1/2 mutations occur in up to 70% of low-grade gliomas and secondary glioblastomas. Mutation of these enzymes reduces the wildtype function of the enzyme (conversion of isocitrate to α-ketoglutarate) while conferring a new enzymatic function, the production of d-2-hydroxyglutara...
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| Publicado no: | Curr Opin Oncol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4612588/ https://ncbi.nlm.nih.gov/pubmed/22080945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCO.0b013e32834d816a |
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