Demethylation and epigenetic modification with 5-azacytidine reduces IDH1 mutant glioma growth in combination with temozolomide

BACKGROUND: Isocitrate deyhydrogenase (IDH) mutant glioma comprises the majority of grades II–III gliomas and nearly all secondary glioblastomas. These progressive gliomas arise from mutations in IDH1 or IDH2 that pathologically produce D-2-hydroxyglutarate (2HG), which interferes with cell reaction...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Yamashita, Alex Shimura, da Costa Rosa, Marina, Borodovsky, Alexandra, Festuccia, William T, Chan, Timothy, Riggins, Gregory J
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Basic and Translational Investigations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6374765/
https://ncbi.nlm.nih.gov/pubmed/30184215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy146
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