Highly Efficient Transgenesis in Ferrets Using CRISPR/Cas9-Mediated Homology-Independent Insertion at the ROSA26 Locus

The domestic ferret (Mustela putorius furo) has proven to be a useful species for modeling human genetic and infectious diseases of the lung and brain. However, biomedical research in ferrets has been hindered by the lack of rapid and cost-effective methods for genome engineering. Here, we utilized...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Yu, Miao, Sun, Xingshen, Tyler, Scott R., Liang, Bo, Swatek, Anthony M., Lynch, Thomas J., He, Nan, Yuan, Feng, Feng, Zehua, Rotti, Pavana G., Choi, Soon H., Shahin, Weam, Liu, Xiaoming, Yan, Ziying, Engelhardt, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6374392/
https://ncbi.nlm.nih.gov/pubmed/30760763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37192-4
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