Mismatch repair-signature mutations activate gene enhancers across human colorectal cancer epigenomes

Commonly-mutated genes have been found for many cancers, but less is known about mutations in cis-regulatory elements. We leverage gains in tumor-specific enhancer activity, coupled with allele-biased mutation detection from H3K27ac ChIP-seq data, to pinpoint potential enhancer-activating mutations...

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Библиографические подробности
Опубликовано в: :eLife
Главные авторы: Hung, Stevephen, Saiakhova, Alina, Faber, Zachary J, Bartels, Cynthia F, Neu, Devin, Bayles, Ian, Ojo, Evelyn, Hong, Ellen S, Pontius, W Dean, Morton, Andrew R, Liu, Ruifu, Kalady, Matthew F, Wald, David N, Markowitz, Sanford, Scacheri, Peter C
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2019
Предметы:
Cancer Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6374075/
https://ncbi.nlm.nih.gov/pubmed/30759065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.40760
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