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Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome

In addition to mutations in genes, aberrant enhancer element activity at non-coding regions of the genome is a key driver of tumorigenesis. Here, we perform epigenomic enhancer profiling of a cohort of more than forty genetically diverse human colorectal cancer (CRC) specimens. Using normal colonic...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Cohen, Andrea J., Saiakhova, Alina, Corradin, Olivia, Luppino, Jennifer M., Lovrenert, Katreya, Bartels, Cynthia F., Morrow, James J., Mack, Stephen C., Dhillon, Gursimran, Beard, Lydia, Myeroff, Lois, Kalady, Matthew F., Willis, Joseph, Bradner, James E., Keri, Ruth A., Berger, Nathan A., Pruett-Miller, Shondra M., Markowitz, Sanford D., Scacheri, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309719/
https://ncbi.nlm.nih.gov/pubmed/28169291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14400
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