Selective targeting of NAMPT by KPT-9274 in acute myeloid leukemia

Treatment options for acute myeloid leukemia (AML) remain extremely limited and associated with significant toxicity. Nicotinamide phosphoribosyltransferase (NAMPT) is involved in the generation of NAD(+) and a potential therapeutic target in AML. We evaluated the effect of KPT-9274, a p21-activated...

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Xehetasun bibliografikoak
Argitaratua izan da:Blood Adv
Egile Nagusiak: Mitchell, Shaneice R., Larkin, Karilyn, Grieselhuber, Nicole R., Lai, Tzung-Huei, Cannon, Matthew, Orwick, Shelley, Sharma, Pratibha, Asemelash, Yerdanose, Zhang, Pu, Goettl, Virginia M., Beaver, Larry, Mims, Alice, Puduvalli, Vinay K., Blachly, James S., Lehman, Amy, Harrington, Bonnie, Henderson, Sally, Breitbach, Justin T., Williams, Katie E., Dong, Shuai, Baloglu, Erkan, Senapedis, William, Kirschner, Karl, Sampath, Deepa, Lapalombella, Rosa, Byrd, John C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2019
Gaiak:
Myeloid Neoplasia
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6373756/
https://ncbi.nlm.nih.gov/pubmed/30692102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018024182
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