EXTH-84. TARGETING THE SALVAGE PATHWAY OF NAD+ GENERATION IN GLIOMAS BY KPT-9274, A NOVEL DUAL INHIBITOR OF PAK4 AND NAMPT

BACKGROUND: Current treatment of glioblastoma (GBM) with surgery and chemoRT yields an average survival of ~1.5 years, highlighting the need for more effective therapies. We have previously reported that PAK4 is a key modulator of radioresistance in GBM. Additionally, pathways that regulate differen...

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Publicado no:Neuro Oncol
Main Authors: Sharma, Pratibha, Kesanakurti, Divya, Wu, Pei-Jung, Xu, Jihong, Sampath, Deepa, Senapedis, William, Baloglu, Erkan, Puduvalli, Vinay K
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693198/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.374
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