ER stress sensor, glucose regulatory protein 78 (GRP78) regulates redox status in pancreatic cancer thereby maintaining “stemness”

Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) signaling have been shown to be dysregulated in multiple cancer types. Glucose regulatory protein 78 (GRP78), the master regulator of the UPR, plays a role in proliferation, invasion, and metastasis in cancer. Cancer stem cell...

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Publicado en:Cell Death Dis
Autores principales: Dauer, Patricia, Sharma, Nikita S., Gupta, Vineet K., Durden, Brittany, Hadad, Roey, Banerjee, Santanu, Dudeja, Vikas, Saluja, Ashok, Banerjee, Sulagna
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6372649/
https://ncbi.nlm.nih.gov/pubmed/30755605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1408-5
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