Inhibition of Sp1 prevents ER homeostasis and causes cell death by lysosomal membrane permeabilization in pancreatic cancer

Endoplasmic reticulum (ER) stress initiates an important mechanism for cell adaptation and survival, named the unfolded protein response (UPR). Severe or chronic/prolonged UPR can breach the threshold for survival and lead to cell death. There is a fundamental gap in knowledge on the molecular mecha...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Dauer, Patricia, Gupta, Vineet K., McGinn, Olivia, Nomura, Alice, Sharma, Nikita S., Arora, Nivedita, Giri, Bhuwan, Dudeja, Vikas, Saluja, Ashok K., Banerjee, Sulagna
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5431512/
https://ncbi.nlm.nih.gov/pubmed/28484232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01696-2
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados