Targeting tumor-intrinsic hexosamine biosynthesis sensitizes pancreatic cancer to anti-PD1 therapy

Pancreatic ductal adenocarcinoma (PDAC) is considered to be a highly immunosuppressive and heterogenous neoplasm. Despite improved knowledge regarding the genetic background of the tumor and better understanding of the tumor microenvironment, immune checkpoint inhibitor therapy (targeting CTLA4, PD1...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Clin Invest
Prif Awduron: Sharma, Nikita S., Gupta, Vineet K., Garrido, Vanessa T., Hadad, Roey, Durden, Brittany C., Kesh, Kousik, Giri, Bhuwan, Ferrantella, Anthony, Dudeja, Vikas, Saluja, Ashok, Banerjee, Sulagna
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2019
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934212/
https://ncbi.nlm.nih.gov/pubmed/31613799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127515
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