Targeting tumor-intrinsic hexosamine biosynthesis sensitizes pancreatic cancer to anti-PD1 therapy

Pancreatic ductal adenocarcinoma (PDAC) is considered to be a highly immunosuppressive and heterogenous neoplasm. Despite improved knowledge regarding the genetic background of the tumor and better understanding of the tumor microenvironment, immune checkpoint inhibitor therapy (targeting CTLA4, PD1...

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Publicado en:J Clin Invest
Autores principales: Sharma, Nikita S., Gupta, Vineet K., Garrido, Vanessa T., Hadad, Roey, Durden, Brittany C., Kesh, Kousik, Giri, Bhuwan, Ferrantella, Anthony, Dudeja, Vikas, Saluja, Ashok, Banerjee, Sulagna
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934212/
https://ncbi.nlm.nih.gov/pubmed/31613799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127515
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