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Reversible fold-switching controls the functional cycle of the antitermination factor RfaH

RfaH, member of the NusG/Spt5 family, activates virulence genes in Gram-negative pathogens. RfaH exists in two states, with its C-terminal domain (CTD) folded either as α-helical hairpin or β-barrel. In free RfaH, the α-helical CTD interacts with, and masks the RNA polymerase binding site on, the N-...

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Bibliografische gegevens
Gepubliceerd in:Nat Commun
Hoofdauteurs: Zuber, Philipp Konrad, Schweimer, Kristian, Rösch, Paul, Artsimovitch, Irina, Knauer, Stefan H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370827/
https://ncbi.nlm.nih.gov/pubmed/30742024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08567-6
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