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Global Implications of Local Unfolding Phenomena, Probed by Cysteine Reactivity in Human Frataxin

Local events that affect specific regions of proteins are of utmost relevance for stability and function. The aim of this study is to quantitatively assess the importance of locally-focused dynamics by means of a simple chemical modification procedure. Taking human Frataxin as a working model, we in...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Faraj, Santiago E., Noguera, Martín E., Delfino, José María, Santos, Javier
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370780/
https://ncbi.nlm.nih.gov/pubmed/30742023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39429-2
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