Optimization of N-benzyl-5-nitrofuran-2-carboxamide as an antitubercular agent

The optimization campaign for a nitrofuran antitubercular hit (N-benzyl-5-nitrofuran-2-carboxamide; JSF-3449) led to the design, synthesis, and biological profiling of a family of analogs. These compounds exhibited potent in vitro antitubercular activity (MIC = 0.019 – 0.20 μM) against the Mycobacte...

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Bibliographic Details
Published in:Bioorg Med Chem Lett
Main Authors: Gallardo-Macias, Ricardo, Kumar, Pradeep, Jaskowski, Mark, Richmann, Todd, Shrestha, Riju, Russo, Riccardo, Singleton, Eric, Zimmerman, Matthew D., Ho, Hsin Pin, Dartois, Véronique, Connell, Nancy, Alland, David, Freundlich, Joel S.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6368976/
https://ncbi.nlm.nih.gov/pubmed/30600207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.12.053
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