Role of CCL5 and CCR5 gene polymorphisms in EGFR signaling blockade in Metastatic Colorectal Cancer: Analysis of the FIRE-3 trial

BACKGROUND: Epidermal growth factor receptor signaling blockade increases CCL5 expression that regulate either the anti-tumor immune response or tumor progression. We investigated the potential role of CCL5/CCR5 axis in cetuximab-based treatment in metastatic colorectal cancer (mCRC) patients. PATIE...

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Publicat a:Eur J Cancer
Autors principals: Suenaga, Mitsukuni, Stintzing, Sebastian, Cao, Shu, Zhang, Wu, Yang, Dongyun, Ning, Yan, Okazaki, Satoshi, Berger, Martin D., Miyamoto, Yuji, Schirripa, Marta, Soni, Shivani, Barzi, Afsaneh, Heinemann, Volker, Lenz, Heinz-Josef
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6367121/
https://ncbi.nlm.nih.gov/pubmed/30554073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2018.11.019
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