Cryo-EM structure of the human α1β3γ2 GABA(A) receptor in a lipid bilayer

Type A γ-aminobutyric acid receptors (GABA(A)Rs) are pentameric ligand-gated ion channels (pLGICs) and the main drivers of fast inhibitory neurotransmission in the vertebrate nervous system1,2. Their dysfunction is implicated in a range of neurological disorders, including depression, epilepsy and s...

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Publicat a:Nature
Autors principals: Laverty, Duncan, Desai, Rooma, Uchański, Tomasz, Masiulis, Simonas, Stec, Wojciech J., Malinauskas, Tomas, Zivanov, Jasenko, Pardon, Els, Steyaert, Jan, Miller, Keith W., Aricescu, A. Radu
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6364807/
https://ncbi.nlm.nih.gov/pubmed/30602789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0833-4
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