Nuclear condensates of the Polycomb protein chromobox 2 (CBX2) assemble through phase separation

Polycomb group (PcG) proteins repress master regulators of development and differentiation through organization of chromatin structure. Mutation and dysregulation of PcG genes cause developmental defects and cancer. PcG proteins form condensates in the cell nucleus, and these condensates are the phy...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Tatavosian, Roubina, Kent, Samantha, Brown, Kyle, Yao, Tingting, Duc, Huy Nguyen, Huynh, Thao Ngoc, Zhen, Chao Yu, Ma, Brian, Wang, Haobin, Ren, Xiaojun
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
Soggetti:
Gene Regulation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6364756/
https://ncbi.nlm.nih.gov/pubmed/30514760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006620
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