Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin

The Polycomb PRC1 plays essential roles in development and disease pathogenesis. Targeting of PRC1 to chromatin is thought to be mediated by the Cbx family proteins (Cbx2/4/6/7/8) binding to histone H3 with a K27me3 modification (H3K27me3). Despite this prevailing view, the molecular mechanisms of t...

詳細記述

保存先:
書誌詳細
出版年:eLife
主要な著者: Zhen, Chao Yu, Tatavosian, Roubina, Huynh, Thao Ngoc, Duc, Huy Nguyen, Das, Raibatak, Kokotovic, Marko, Grimm, Jonathan B, Lavis, Luke D, Lee, Jun, Mejia, Frances J, Li, Yang, Yao, Tingting, Ren, Xiaojun
フォーマット: Artigo
言語:Inglês
出版事項: eLife Sciences Publications, Ltd 2016
主題:
Biophysics and Structural Biology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056789/
https://ncbi.nlm.nih.gov/pubmed/27723458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17667
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