Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin

The Polycomb PRC1 plays essential roles in development and disease pathogenesis. Targeting of PRC1 to chromatin is thought to be mediated by the Cbx family proteins (Cbx2/4/6/7/8) binding to histone H3 with a K27me3 modification (H3K27me3). Despite this prevailing view, the molecular mechanisms of t...

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Detaylı Bibliyografya
Yayımlandı:eLife
Asıl Yazarlar: Zhen, Chao Yu, Tatavosian, Roubina, Huynh, Thao Ngoc, Duc, Huy Nguyen, Das, Raibatak, Kokotovic, Marko, Grimm, Jonathan B, Lavis, Luke D, Lee, Jun, Mejia, Frances J, Li, Yang, Yao, Tingting, Ren, Xiaojun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications, Ltd 2016
Konular:
Biophysics and Structural Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056789/
https://ncbi.nlm.nih.gov/pubmed/27723458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17667
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