Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin

The Polycomb PRC1 plays essential roles in development and disease pathogenesis. Targeting of PRC1 to chromatin is thought to be mediated by the Cbx family proteins (Cbx2/4/6/7/8) binding to histone H3 with a K27me3 modification (H3K27me3). Despite this prevailing view, the molecular mechanisms of t...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Zhen, Chao Yu, Tatavosian, Roubina, Huynh, Thao Ngoc, Duc, Huy Nguyen, Das, Raibatak, Kokotovic, Marko, Grimm, Jonathan B, Lavis, Luke D, Lee, Jun, Mejia, Frances J, Li, Yang, Yao, Tingting, Ren, Xiaojun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2016
Onderwerpen:
Biophysics and Structural Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056789/
https://ncbi.nlm.nih.gov/pubmed/27723458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17667
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