Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin

The Polycomb PRC1 plays essential roles in development and disease pathogenesis. Targeting of PRC1 to chromatin is thought to be mediated by the Cbx family proteins (Cbx2/4/6/7/8) binding to histone H3 with a K27me3 modification (H3K27me3). Despite this prevailing view, the molecular mechanisms of t...

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Udgivet i:eLife
Main Authors: Zhen, Chao Yu, Tatavosian, Roubina, Huynh, Thao Ngoc, Duc, Huy Nguyen, Das, Raibatak, Kokotovic, Marko, Grimm, Jonathan B, Lavis, Luke D, Lee, Jun, Mejia, Frances J, Li, Yang, Yao, Tingting, Ren, Xiaojun
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2016
Fag:
Biophysics and Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056789/
https://ncbi.nlm.nih.gov/pubmed/27723458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17667
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