Phase-Separated Transcriptional Condensates Accelerate Target-Search Process Revealed by Live-Cell Single-Molecule Imaging

Compartmentalization by liquid-liquid phase separation is implicated in transcription. It remains unclear whether and how transcriptional condensates accelerate the search of transcriptional regulatory factors for their target sites. Furthermore, the molecular mechanisms by which regulatory factors...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Kent, Samantha, Brown, Kyle, Yang, Chou-hsun, Alsaihati, Njood, Tian, Christina, Wang, Haobin, Ren, Xiaojun
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7593837/
https://ncbi.nlm.nih.gov/pubmed/33053359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108248
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