Phase-Separated Transcriptional Condensates Accelerate Target-Search Process Revealed by Live-Cell Single-Molecule Imaging

Compartmentalization by liquid-liquid phase separation is implicated in transcription. It remains unclear whether and how transcriptional condensates accelerate the search of transcriptional regulatory factors for their target sites. Furthermore, the molecular mechanisms by which regulatory factors...

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Vydáno v:Cell Rep
Hlavní autoři: Kent, Samantha, Brown, Kyle, Yang, Chou-hsun, Alsaihati, Njood, Tian, Christina, Wang, Haobin, Ren, Xiaojun
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7593837/
https://ncbi.nlm.nih.gov/pubmed/33053359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108248
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