Ligand-induced conformational switch in an artificial bidomain protein scaffold

Artificial proteins binding any predefined “target” protein can now be efficiently generated using combinatorial libraries based on robust protein scaffolds. αRep is such a family of artificial proteins, based on an α-solenoid protein repeat scaffold. The low aggregation propensity of the specific “...

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Publicado no:Sci Rep
Main Authors: Léger, Corentin, Di Meo, Thibault, Aumont-Nicaise, Magali, Velours, Christophe, Durand, Dominique, Li de la Sierra-Gallay, Ines, van Tilbeurgh, Herman, Hildebrandt, Niko, Desmadril, Michel, Urvoas, Agathe, Valerio-Lepiniec, Marie, Minard, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6362204/
https://ncbi.nlm.nih.gov/pubmed/30718544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37256-5
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