Ligand-induced conformational switch in an artificial bidomain protein scaffold

Artificial proteins binding any predefined “target” protein can now be efficiently generated using combinatorial libraries based on robust protein scaffolds. αRep is such a family of artificial proteins, based on an α-solenoid protein repeat scaffold. The low aggregation propensity of the specific “...

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Pubblicato in:Sci Rep
Autori principali: Léger, Corentin, Di Meo, Thibault, Aumont-Nicaise, Magali, Velours, Christophe, Durand, Dominique, Li de la Sierra-Gallay, Ines, van Tilbeurgh, Herman, Hildebrandt, Niko, Desmadril, Michel, Urvoas, Agathe, Valerio-Lepiniec, Marie, Minard, Philippe
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6362204/
https://ncbi.nlm.nih.gov/pubmed/30718544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37256-5
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