Ligand-induced conformational switch in an artificial bidomain protein scaffold

Artificial proteins binding any predefined “target” protein can now be efficiently generated using combinatorial libraries based on robust protein scaffolds. αRep is such a family of artificial proteins, based on an α-solenoid protein repeat scaffold. The low aggregation propensity of the specific “...

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Publicat a:Sci Rep
Autors principals: Léger, Corentin, Di Meo, Thibault, Aumont-Nicaise, Magali, Velours, Christophe, Durand, Dominique, Li de la Sierra-Gallay, Ines, van Tilbeurgh, Herman, Hildebrandt, Niko, Desmadril, Michel, Urvoas, Agathe, Valerio-Lepiniec, Marie, Minard, Philippe
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6362204/
https://ncbi.nlm.nih.gov/pubmed/30718544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37256-5
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