Endogenous Neurosteroid (3α,5α)3-Hydroxypregnan-20-one Inhibits Toll-like-4 Receptor Activation and Pro-inflammatory Signaling in Macrophages and Brain

The endogenous neurosteroid (3α,5α)3-hydroxypregnan-20-one (3α,5α-THP, allopregnanolone) has protective activity in animal models of alcoholism, depression, traumatic brain injury, schizophrenia, multiple sclerosis, and Alzheimer’s disease that is poorly understood. Because these conditions involve...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Balan, Irina, Beattie, Matthew C., O’Buckley, Todd K., Aurelian, Laure, Morrow, A. Leslie
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6362084/
https://ncbi.nlm.nih.gov/pubmed/30718548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37409-6
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