Neuroactive Steroid (3α,5α)3-hydroxypregnan-20-one (3α,5α-THP) and Pro-inflammatory Cytokine MCP-1 Levels in Hippocampus CA1 are Correlated with Voluntary Ethanol Consumption in Cynomolgus Monkey

BACKGROUND: Neuroactive steroids such as (3α,5α)3-hydroxypregnan-20-one (3α,5α-THP, allopregnanolone) are potent neuromodulators that enhance GABAergic neurotransmission and produce inhibitory neurobehavioral and anti-inflammatory effects. Chronic ethanol consumption reduces 3α,5α-THP levels in huma...

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Опубликовано в: :Alcohol Clin Exp Res
Главные авторы: Beattie, Matthew C., Reguyal, Christopher S., Porcu, Patrizia, Daunais, James B., Grant, Kathleen A., Morrow, A. Leslie
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750072/
https://ncbi.nlm.nih.gov/pubmed/29112774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.13545
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