Voluntary Ethanol Consumption Reduces GABAergic Neuroactive Steroid (3α,5α)3-hydroxypregnan-20-one (3α,5α-THP) in the Amygdala of the Cynomolgus Monkey

Neuroactive steroids such as (3α,5α)3-hydroxypregnan-20-one (3α,5α-THP, allopregnanolone) enhance the GABAergic effects of ethanol and modulate excessive drinking in rodents. Moreover, chronic ethanol consumption reduces 3α,5α-THP levels in human plasma, rat hippocampus, and mouse limbic regions. We...

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Detalhes bibliográficos
Publicado no:Addict Biol
Main Authors: Beattie, Matthew C., Maldonado-Devincci, Antoniette M., Porcu, Patrizia, O’Buckley, Todd K., Daunais, James B., Grant, Kathleen A., Morrow, A. Leslie
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896863/
https://ncbi.nlm.nih.gov/pubmed/26625954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/adb.12326
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