Cellular GABAergic neuroactive steroid (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP) immunostaining levels are increased in the ventral tegmental area of the human Alcohol Use Disorder patients: A postmortem study

BACKGROUND: The GABAergic neuroactive steroid (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP, allopregnanolone) enhances GABAergic activity and produces subjective effects similar to ethanol. The effect of chronic alcohol exposure on 3α,5α-THP concentrations has been studied in mouse, rat, and monkey l...

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Bibliografiset tiedot
Julkaisussa:Alcohol Clin Exp Res
Päätekijät: Hasirci, A. Sait, Maldonado-Devincci, Antoniette M., Beattie, Matthew C., O'Buckley, Todd K., Morrow, A. Leslie
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5272786/
https://ncbi.nlm.nih.gov/pubmed/28068457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.13300
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