Reduction of circulating and selective limbic brain levels of (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP) following forced swim stress in C57BL/6J mice

RATIONALE: Stress activates the hypothalamic-pituitary-adrenal (HPA) axis, and GABAergic neuroactive steroids contribute to homeostatic regulation of this circuitry. Acute forced swim stress (FSS) increases plasma, cortical, and hypothalamic (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP) levels in rat...

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Detalhes bibliográficos
Publicado no:Psychopharmacology (Berl)
Main Authors: Maldonado-Devincci, Antoniette M., Beattie, Matthew C., Morrow, Danielle H., McKinley, Raechel E., Cook, Jason B., O’Buckley, Todd K., Morrow, A. Leslie
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335654/
https://ncbi.nlm.nih.gov/pubmed/24744202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-014-3552-z
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