Neurosteroid allopregnanolone (3α,5α-THP) inhibits inflammatory signals induced by activated MyD88-dependent toll-like receptors

We have shown that endogenous neurosteroids, including pregnenolone and 3α,5α-THP inhibit toll-like receptor 4 (TLR4) signal activation in mouse macrophages and the brain of alcohol-preferring (P) rat, which exhibits innate TLR4 signal activation. The current studies were designed to examine whether...

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Detalhes bibliográficos
Publicado no:Transl Psychiatry
Main Authors: Balan, Irina, Aurelian, Laure, Schleicher, Riana, Boero, Giorgia, O’Buckley, Todd, Morrow, A. Leslie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7909379/
https://ncbi.nlm.nih.gov/pubmed/33637705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-021-01266-1
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